LibGuides: Evidence Based Medicine (Practice): EBM/Practice Pyramid & Tutorials

Core Curriculum

Jama Evidence
Online tools for understanding and applying the medical literature and making clinical diagnoses. Includes the text of the Users Guide to the Medical Literature, and the Rational Clinical Examination.
Users' Guide to the Medical Literature
3rd Ed. Guyatt, Rennie, Meade, & Cook (2015)
The Rational Clinical Examination
Simel & Rennie (2009)
Evidence-based Medicine: How to Practice and Teach EBM
3rd Ed. Sackett (2005) and others
Evidence-based Health Care Workbook: Bridging the Gap Between Health Care Research and Practice
How to Read a Paper: The Basics of Evidence-Based Medicine and Healthcare
Greenhalgh (2019) and others

The type of question will often dictate the best study design to address the question:

Key: best - to - adequate, or what is available on topic

Question: Study:

Clinical Examination Prospective, blind comparison to the Gold Standard

Diagnostic Testing Prospective, blind comparison to the Gold Standard

Prognosis Cohort Study - Case Control- Case Series

Therapy RCT- Cohort Study- Case Control - Case Series

Etiology/Harm RCT - Cohort Study - Case Control - Case Series

Prevention RCT- Cohort Study - Case Control - Case Series

Moving toward the post p < 0.05 era via the analysis of credibility.
From American Statistician, 2019.Matthews, R. doi:10.1080/00031305.2019.1583973
The Problem with p and Statistical Significance
From Nursing Research, 2019. Pickler, R. DOI: 10.1097/NNR.0000000000000391
Understanding Statistical Significance
From Nursing Research, 2010. Hayat, M. J.

EBM Tutorial
This tutorial was developed by staff at Duke University Medical Center Library and the Health Sciences Library at the University of North Carolina at Chapel Hill.

Building Clinical Questions Using PICO
P =Patient or Problem

I =Intervention

C = Comparison

O = Outcome
PICO Question Templates by Type of Clinical Question
Etiology, Diagnosis, Treatment, Intervention, Quality of Life, Therapy

Cochrane Evidence Essentials - Evidence-Based Medicine
Evidence-based medicine, randomized controlled trials, introduction to systematic reviews, understanding systematic reviews
more...less...
This learning has been co-produced by healthcare consumers, researchers and specialists from Cochrane’s Central Executive Team, with contributions from a range of experts in their fields.

How Do I Interpret a Confidence Interval?
From Transfusion, 2016. O'brien & Yi. doi: 10.1111/trf.13635
Confidence Interval or P-Value?
From Dtsch Arztebl International, 2009. Du prel et al. doi: 10.3238/arztebl.2009.0335
Video: Understanding Confidence Intervals
Includes information about sampling and sampling error.