All of Us Research Program: Research Project 1

Workspace name: 

Data access tier: Registered Tier (The Registered Tier includes data from electronic health records (EHRs), wearables, surveys, and physical measurements) OR Controlled Tier (In addition to the data in the Registered Tier, the Controlled Tier dataset contains genomic data in the form of short-read whole genome sequences (WGS), long-read WGS, structural variants, and genotyping arrays; previously suppressed demographic data fields from EHRs and surveys; and unshifted dates of events). USD has access to Controlled Tier.

Dataset version: Select which version of Curated Data Repository you wish to query in this workspace—recommended - Most recent version. 

Research Use Statement Questions 

1. What is the primary purpose of your project?
2. Please provide a summary of your research purpose by responding to the questions below
   1. What are the specific scientific question(s) you intend to study, and why is the question important (i.e. relevance to science or public health)?
   2. What are the scientific approaches you plan to use for your study? Describe the datasets, research methods, and tools you will use to answer your scientific question(s).
   3. What are the anticipated findings from the study? How would your findings contribute to the body of scientific knowledge in the field?
3. The All of Us Research Program encourages researchers to disseminate their research findings to both scientific and lay/community audiences, to maximize the value of the resource and to recognize the contributions of participant partners. Please tell us how you plan to disseminate your research findings. Choose as many options below as applicable, and specify details in the text box, if available.
4. The All of Us Research Program would like to understand how (or if) your research outcome may fit into the All of Us Research Program Scientific Framework. Please select all of the statements below that describe the outcomes you anticipate from your research.
5. Population of interest. Will your study focus on any historically underrepresented populations?
6. All of Us has a policy on respectful research involving American Indian and Alaska Native (AI/AN) populations. The following questions are intended to assess the relevance of the policy to your research.
   1. Does your research plan require any of the following with respect to individuals who self-identify as American Indian or Alaska Native (AI/AN) or who are genetically similar to populations with inferred Indigenous American genetic ancestry? Select the option that best describes your plans.
   2. Please explain your response by sharing specific details about your study design.
7. Request for Review of Research Purpose Description. Would you like to request a review of your research purpose statement by the Resource Access Board?

Include: type 2 diabetes (condition) AND metformin (drug) AND a1c (labs & measurements)

Exclude: pregnant (condition)

1. Metformin (drug)
2. A1c (labs & measurement)

Combine the Cohort AND Concept Sets

• You can drop the column you might not need in your analysis here, under the “3. Select Values (Columns)”.
• “4. Preview Dataset” offers the opportunity to preview the dataset before exporting it for analysis.

Select your preferred programming language to use from Python, R, and SAS.