“Thin endometrium” at single-cell resolutionThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S135-S148 | Zhang, Xiwen, MB; Lv, Haining, MD, PhD; Weng, Qiao, MD;...Thin endometrium is defined as an endometrial thickness of less than 7 mm in the midluteal phase of the menstrual cycle, a condition often seen in women of childbearing age with a history of uterine trauma, such as dilation and curettage or intrau...
Asherman syndrome at single-cell resolutionThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S148-S159 | Pardo-Figuerez, María, PhD; Simon, Carlos, MD, PhD; Santamaria, Xavier, MD, PhDThis comprehensive review aimed to provide insights into the Asherman syndrome’s historical background, clinical manifestations, classifications, obstetrical challenges, and current treatment approaches. The syndrome is characterized by intrauteri...
Placenta at single-cell resolution in early and late preeclampsia: insights and clinical implicationsThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S176-S189 | Solt, Ido, MD; Cohen, Sarah M., MPH; Admati, Inbal, PhD;...Preeclampsia, one of the great obstetrical syndromes, manifests through diverse maternal and fetal complications and remains a leading contributor to adverse perinatal outcomes. In this review, we describe our work on single-cell and single-nuclei...
The adult ovary at single cell resolution: an expert reviewThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S95.e1-S95.e16 | Rooda, Ilmatar, PhD; Méar, Loren, PhD; Hassan, Jasmin, PhD;...The ovaries play a crucial role in both the endocrine health and fertility of adult women. The fundamental functional units of the ovaries, primordial follicles, form during fetal development and constitute the ovarian reserve. Ovaries age prematu...
Single-cell technology: the key to an improved understanding of the human endometrium in health and diseaseThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S43-S53 | Gonzalez-Fernandez, Javier, MSc; Zaragozano, Sofía, MSc; Monteagudo-Sánchez, Ana, PhD;...Cyclic exposure of the endometrium to ovarian sex steroids during the menstrual cycle induces a transition between proliferative and receptive states involving a different variety of cell types (ie, epithelial, stromal, endothelial, and immune cel...
How to view the female reproductive tract through single-cell looking glassesThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S21-S43 | Llera-Oyola, Jaime, MD; Pérez-Moraga, Raúl, MD; Parras, Marcos, PhD;...Single-cell technologies have emerged as an unprecedented tool for biologists and clinicians, allowing them to assess organs and tissues at the level of individual cells. In the field of women's reproductive biology, single-cell studies have provi...
Endometriosis and adenomyosis unveiled through single-cell glassesThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S105-S123 | Giudice, Linda C., MD, PhD; Liu, Binya, MD, PhD; Irwin, Juan C., MD, PhDSingle-cell technologies are expanding our understanding of endometriosis and adenomyosis, which are sister disorders of the uterine endometrium that contain similar complements of lesion cell types but in different locations–outside and inside th...
Cervical function in pregnancy and disease: new insights from single-cell analysisThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, Supplement, 2025 Apr, Pages S81-S94 | Madhukaran, ShanmugaPriyaa, PhD; Fomina, Yevgenia Y., MD; Mahendroo, Mala, PhDThe uterine cervix plays an essential role in regulating fertility, maintaining pregnancy, remodeling in preparation for parturition, and protecting the reproductive tract from infection. A compromise in cervical function contributes to adverse cl...
Quantifying the association between doula care and maternal and neonatal outcomesThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, 2025 Apr, Pages 387.e1-387.e43 | Lemon, Lara S., PharmD, PhD; Quinn, Beth, RN; Young, Melissa, RN;...BackgroundThe United States suffers from an increasing rate of severe maternal morbidity, paired with a wide disparity in maternal health by race. Doulas are posited to be a useful resource to increase positive outcomes and to decrease this dispar...
Introduction of a nationwide first-trimester anomaly scan in the Dutch national screening programThis link opens in a new windowAmerican Journal of Obstetrics and Gynecology, Volume 232, Issue 4, 2025 Apr, Pages 396.e1-396.e19 | Lust, Eline E.R., MSc; Bronsgeest, Kim, MSc; Henneman, Lidewij, PhD;...BackgroundA significant proportion of major fetal structural anomalies can be detected in the first trimester by ultrasound examination. However, the test performance of the first-trimester anomaly scan performed in a low-risk population as part o...
